Spread bets and CFDs are complex instruments and come with a high risk of losing money rapidly due to leverage. 76% of retail investor accounts lose money when trading spread bets and CFDs with this provider. You should consider whether you understand how spread bets and CFDs work, and whether you can afford to take the high risk of losing your money.
Spread bets and CFDs are complex instruments and come with a high risk of losing money rapidly due to leverage. 76% of retail investor accounts lose money when trading spread bets and CFDs with this provider. You should consider whether you understand how spread bets and CFDs work, and whether you can afford to take the high risk of losing your money.

4D Pharma shares receive trial data boost

4D Pharma shares have jumped following positive clinical trial results. Where next for the biotech?

Source: Bloomberg

Shares in 4D Pharma received a welcome boost this week after the company posted positive results from a clinical trial of its early-stage cancer drug. In Phase I/II trials the product hit its end point early in treating patients with kidney cancer. The drug was administered in combination with Merck’s drug Keytruda. 4D Pharma has a research partnership in place with the drug giant.

Shares in the biotech jumped 29% to 58p following the encouraging test results, although they have since fallen back to 48p.

"Today's results in renal cell carcinoma, meeting the predefined primary efficacy endpoint early in this difficult to treat population, marks another important step forward for MRx0518 and the increasing importance of the microbiome in cancer treatment," said the company’s chief scientific officer, Dr Alex Stevenson.

Chief executive Duncan Peyton told IGTV that the data was "really meaningful... in proving [4D Pharma's] thesis."


4D Pharma’s ‘drugs from bugs’


The biotech company is developing a stable of drugs to treat cancer, Parkinson’s disease, irritable bowel syndrome and asthma. Its pipeline of five products is based on bacteria found in the human gut - what it terms ‘live biotherapeutics’ from the human microbiome.

4D Pharma is dual-listed on AIM and Nasdaq and has a market capitalisation of just £91m. Two of its Parkinson’s disease products also recently received the go ahead from the US regulator to enter clinical trials.

Trading at just 48p, the shares have lost two-thirds of their value since reaching a high of 156p in September 2020 - 56% in the past year.

4D Pharma burning through cash

Developing drugs is an expensive business. The biotech burned through £56m last year and only has £20m in funding left, making it likely that a cash call will be required later this year. Certainly, management said at its recent half-year results that it has enough funds to take it through to the fourth-quarter of 2022.

4D Pharma also has a $30m cash facility lined up with Oxford Finance. The company recently signalled it may list up to $150m of shares on Nasdaq as American depository shares, following a filing with the US Security and Exchange Commission.

Investing in biotech companies is high risk and Phase III clinical trials can prove costly. It can take more than a $1bn to bring a new drug to market. Failure rates are high and it is common for even late-stage products to fail in the clinic. The bulk of 4D Pharma’s drugs are still relatively early-stage, with two at the Phase II stage.

The company’s technology is promising but it will need to raise further cash this year. However, securing a licensing deal or other positive trial-related news flow could provide a further boost for the shares. Its partnership with Merck is also a plus point.

Go short and long with spread bets, CFDs and share dealing on 16,000+ shares with the UK’s No.1 platform.* Learn more about trading shares with us, or open an account to get started today.
* Best trading platform as awarded at the ADVFN International Financial Awards 2021

This information has been prepared by IG, a trading name of IG Markets Limited. In addition to the disclaimer below, the material on this page does not contain a record of our trading prices, or an offer of, or solicitation for, a transaction in any financial instrument. IG accepts no responsibility for any use that may be made of these comments and for any consequences that result. No representation or warranty is given as to the accuracy or completeness of this information. Consequently any person acting on it does so entirely at their own risk. Any research provided does not have regard to the specific investment objectives, financial situation and needs of any specific person who may receive it. It has not been prepared in accordance with legal requirements designed to promote the independence of investment research and as such is considered to be a marketing communication. Although we are not specifically constrained from dealing ahead of our recommendations we do not seek to take advantage of them before they are provided to our clients. See full non-independent research disclaimer and quarterly summary.

Act on share opportunities today

Go long or short on thousands of international stocks with spread bets and CFDs.

  • Get full exposure for a comparatively small deposit
  • Trade on spreads from just 0.1%
  • Get greater order book visibility with direct market access

See opportunity on a stock?

Try a risk-free trade in your demo account, and see whether you’re on to something.

  • Log in to your demo
  • Take your position
  • See whether your hunch pays off

See opportunity on a stock?

Don’t miss your chance – upgrade to a live account to take advantage.

  • Trade a huge range of popular stocks
  • Analyse and deal seamlessly on fast, intuitive charts
  • See and react to breaking news in-platform

See opportunity on a stock?

Don’t miss your chance. Log in to take advantage while conditions prevail.

Live prices on most popular markets

  • Equities
  • Indices
  • Forex
  • Commodities
website terms and agreements. Prices are indicative only. All share prices are delayed by at least 15 minutes.

" edit-mode="false" style="--live-prices-table-rows:5" >


Prices above are subject to our website terms and agreements. Prices are indicative only. All share prices are delayed by at least 15 minutes.

Prices above are subject to our website terms and agreements. Prices are indicative only. All shares prices are delayed by at least 15 mins.

Plan your trading week

Get the week’s market-moving news sent directly to your inbox every Sunday. The Week Ahead gives you a full calendar of upcoming economic events, as well as commentary from our expert analysts on the key markets to watch.


For more info on how we might use your data, see our privacy notice and access policy and privacy webpage.

You might be interested in…

Find out what charges your trades could incur with our transparent fee structure.

Discover why so many clients choose us, and what makes us a world-leading provider of spread betting and CFDs.

Stay on top of upcoming market-moving events with our customisable economic calendar.